Evalution of la positive cells in the canine lung transplantation
نویسنده
چکیده
The rejection process related to Ia-positive cells consisting of the lymphocytes of bronchoalveolar lavage (BAL) was mainly evaluated at rejection of lung allotransplantation and also the inhibitory effect of CsA on occuring rejection is assessed. 1) In BAL taken from the transplanted lung, the increase in Ia positive rate and cell population was noted. Meanwhile in B-cells, activated T lymphocytes were remarkably increased in number. 2) The Ia positive rate in alveolar macrophages was the highest in the rejected lung. On the other hand in monocytes of the peripheral blood it was apparently reduced with statistical significance. 3) In virto study, the Ia positive rate of the lymphocytes in BAL was increased by PHA stimulation and significantly reduced by the addition of CsA. The Ia positive rate of macrophages in BAL also tended to be inhibited by adding CsA. The result enabled me to conclude that CsA acts as the elimination of Ia-positive rate in BAL lymphocytes and macrophages. 4) In the rejected lung a cluster of Ia-positive cells was seen not only around small vessels but in the alveolar space. Of interest is the fact that the role of Ia-positive cells is crucial to rejection of lung allografts.
منابع مشابه
Studies on the immunogenic properties of La Sota NDV propagated in embryo lung primary cells culture
متن کامل
Transplantation and Homing of Mouse Embryonic Stem Cells Treated with Erythropoietin in Spleen and Liver of irradiated mice
Background: The present study was designed to evaluate the homing potential of mouse embryonic stem cells (ESC) treated with erythropoietin (EPO) in hematopoietic organs such as spleen and liver after transplantation using morphological and immuno-histochemical techniques. Methods: Day-four embryoid body (EB)-derived cells were dissociated and re-plated in medium in the presence and absence of ...
متن کاملCanine Mammary Gland Cancer Stem Cell and its Potential Role in Malignant Biologic Behavior
BACKGROUND:Canine mammary gland cancers are the most prevalent malignancies in dogs. There are different challenges regarding management of these cancers in dogs and human, one hypothesis is related to small cellular subset of tumor mass called cancer stem cell. These cells are therapy resistant and cause metastasis and relapse even after primary successful treatment. The well-identified phenot...
متن کاملCauses of family refusal for organ donation in brain-dead cases, A Narrative Review
Introduction: One of the most important barriers to organ transplantation and the consequent mortality of people on the waiting list for transplants in most countries is family refusal. As a result, recognizing the effective factors in family consent will provide a bridge to increase the rate of supply of organs needed for transplantation. Due to the various factors affecting organ donation, in...
متن کاملI-12: Follicular Loss of Cryopreserved CanineOvary after Xenotransplantation and its Solution
Advances in the diagnosis and treatment of cancer have resulted in a growing population of adolescent and adult long-term survivors of malignancies with infertility problems due to induced premature ovarian failure. Although several options are currently available to preserve fertility in cancer patients, cryopreservation of ovarian tissue is the only option available for prepubertal girls and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016